Effect of Articular Immobilization - Induced Hindlimb Skeletal Muscle Atrophy on Autophosphorylation of Tyrosine Kinase of the Insulin Receptor in Rats / 대한정형외과학회잡지

The purpose of this study was to investigate the effects of articular immobilization-induced hindlimb skeletal muscle atrophy on the autophosphorylation of the insulin receptor tyrosine kinase in rats. Rats were divided control, and knee and ankle joint immobilized groups. The experiments were performed on the 3rd, 7th, and 21st day after the immobilization. immobilization was induced by k-wire fixation in knee and ankle joint. The ratio of soleus muscle weight to body weight was decreased in proportion to the duration of the immobilization. The glycogen content of the soleus muscle was decreased significantly (p<0.01) at the 7th day, but this value was recovered to 65% of control at the 21st day after the immobilization. The insulin bindings at various concentrations of insulin to wheat-germ agglutinin purified insulin receptor from red gastrocnemius muscle at the 7th day after immobilization were not changed compared to control. The autophosphorylation of the insulin receptor tyrosine kinase with 10-8 and 10-7 M insulin concentration at the 7th day after immobilization was decreased compared to control. In conclusion, above results showed that insulin resistance of immobilized rat hindlimb skeletal muscle was arised from defect of autophosphorylation of the insulin receptor tyrosine kinase in part.

A clinical data management by personal computer in orthopaedics / 대한정형외과학회잡지

No abstract available.

Low Back pain in Young Athletes: Epidemilogic Study of Risk Factors / 대한정형외과학회잡지

Epidemilologic information about various syndromes in low back pain has been regarded by Vert Mooney as one of the important sources for establishing prognosis and providing a rationale for therapy. Several risk factors about low back pain and injuries were analyzed through a questionnaire filled out by 172 athletes of various kind of sports including students and professional players. The following results were obtained. 1. Types of sports were associated with the incidence of low back injuries and gymnastics were included in high risk groups (p<0.01). 2. Career is also associated with the incidence of low back injuries (p<0.05). 3. Pain pattern, such as anterior element pain or posterior element pain is also associated with the particular type of sport(p<0.001). 4. Over-use has been suspected as a main cause of sports injury in 37.8% of athletes. Neglect of warming-up, psychologic attitudes and chronic accumulation of micro-trauma have been also suspected (p<0.001). 5. Management of pain was expected to be received from physiotherapists by 34.2%, from coaches or fellow sportsmen by 24.6%, from an acupuncturist by 17.5%, from doctors by 9.7%, and from trainers by 14% of athletes. However 66.7% of the professional players wanted to receive management of pain from trainers (p<0.001).

Stress Distribution on the Tibio / 대한정형외과학회잡지

To observe the change in the status of stresses according to size of the meniscus, a 3-dimensional photoelasticity model of the knee joint was made of epoxy. Three kinds of meniscus models were made of rubber. Through the axial application of a vertical compressive load of 8kg equivalent to the joint reaction of 3,000N in the human knee joint, the peculiar patterns of the isochromatic fringes were observed and stresses around the knee joint were analyzed according to the size of the defect in the medial meniscus. Even distribution of the photoelasticity fringe patterns were observed in the normal knee joint model with both menisci intact. Stress concentration was increased at the margin of the medial side of the knee joint model with the medial menicus removed partially in about 30-50% of its central portion. In addition, the magnitude of stresses were also noted as increased in the lateral part of this type model. In the knee joint model with nearly all of the medial meniscus removed, strssess were concentrated markedly in the central portion of the knee joint just outside of both tibial spines. Stress was increased in its magnitude according to the size of the defect of the meniscus, and was focalized after menisectomy. In the model for partial menisectomy, the maximum stress concentration point of the removed side migrated to the margin of the same side of the joint. But in the model of total menisectomy, maximum stress concentration points of both side were more centralized. Not only an increment of stresses in magnitude but also centralization of the maximum stress concentration point in its location could contribute to the degenerative process of the knee joint after menisectomy. In addition, articular cartilage can be easily damaged with a relatively small amount of external force.